反应详情

温度

110 °C

8-Fluoro-7-trifluoromethyl-3,4-dihydro-2H-isoquinolin-1-one (I-47d: 150 mg, 0.643 mmol) was reacted with 3-iodo-4-methyl-pyridine (140.98 mg, 0.643 mmol), K3PO4 (346.76 mg, 1.607 mmol), trans-N,N′-dimethyl-cyclohexane-1, 2-diamine (0.03 mL, 0.192 mmol), CuI (12.24 mg, 0.0643 mmol) and 1,4-dioxane (10 mL). The resulting mixture was refluxed for 16 hours at 110° C. to afford the crude product. Purification by column chromatography on silica gel (40% ethylacetate in hexane) followed by preparative HPLC afforded 10 mg of the product (4.8% yield).

1. customto afford the crude product
2. customPurification by column chromatography on silica gel (40% ethylacetate in hexane)