反应详情

温度

52 °C

MnO2 (4.298 g, 49.45 mmol) was added to a solution of (5-fluorobenzo[b]-thiophen-2-yl)methanol (I-50b: 1.8 g, 9.89 mmol) in DCM (50 mL) and the resulting reaction mass was stirred at 52° C. for 2 hours. The reaction was monitored by TLC (30% ethyl acetate in hexane). The reaction mass was cooled to room temperature, filtered off the catalyst through a celite bed and washed the celite bed with DCM. The filtrate was concentrated under reduced pressure and dried under vacuum to afford 1.5 g of the product (88.23% yield).

1. customthe resulting reaction mass
2. temperatureThe reaction mass was cooled to room temperature
3. filtrationfiltered off the catalyst through a celite bed
4. washwashed the celite bed with DCM
5. concentrationThe filtrate was concentrated under reduced pressure
6. customdried under vacuum