反应详情

Using an analogous procedure and workup as described in example 1, for the preparation of Intermediate I-1a above, 5-fluorobenzo[b]thiophene-2-carbaldehyde (1.7 g, 9.444 mmol) was reacted with nitro methane (576.11 mg, 9.444 mmol), 10N NaOH (396.64 mg, 9.916 mmol) and ethanol (25 mL) at 0° C. for 2 hours to afford 1.2 g of the product (57.14% yield).