反应详情

温度

105 °C

Tert-butyl 3-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-3-oxopropylcarbamate (I-59b: 50 g, 158.57 mmol) was dissolved in ethyl acetate (500 mL) at room temperature under nitrogen atmosphere and the resulting reaction mass was heated at 105° C. for 20 hours. The reaction was monitored by TLC (10% methanol in DCM). The reaction mass was cooled to room temperature and concentrated under reduced pressure to afford the crude product. Purification by ether-wash afforded 28 g of the product (83% yield).

1. customthe resulting reaction mass
2. temperatureThe reaction mass was cooled to room temperature
3. concentrationconcentrated under reduced pressure
4. customto afford the crude product
5. customPurification by ether-
6. washwash