化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → 3-(2-Ethoxy-2-oxoethyl)pyridine-1-oxide ethyl iodide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Iodoethane | HCID 6340 | — |
| 反応物 | 3-Pyridineacetic acid, ethyl ester, 1-oxide | HCID 4210360 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 3-(2-Ethoxy-2-oxoethyl)pyridine-1-oxide ethyl iodide | HCID 89964688 | 59% |
反応手順
3-(2-Ethoxy-2-oxoethyl)pyridine-1-oxide (I-67a: 4.8 g, 26.66 mmol) in iodoethane (7.67 mL, 95.99 mmol) was stirred at room temperature for 144 hours under nitrogen atmosphere. The reaction was monitored by TLC (10% methanol in chloroform). The reaction mass was concentrated under reduced pressure to afford 5.3 g of the crude product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08946260B2 |
| 出典データセット | uspto-grants-2015_02 |
| ORD ID | ord-ae326f8fcba5473db0f15e2b46186ccc |
| 出典メモ | uspto-grants-2015_02 |