HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 3-(2-Hydroxyethyl)isonicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Ethyl 2-(4-cyanopyridin-3-YL)acetate | HCID 12251980 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(2-Hydroxyethyl)isonicotinonitrile | HCID 89964755 | 36.3% |
Reaction Steps
Ethyl 2-(4-cyanopyridin-3-yl)acetate (2.3 g, 12.10 mmol) was reacted with NaBH4 (919 mg, 24.21 mmol) and ethanol (20 mL) at room temperature for 72 hours to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCl3) afforded 650 mg of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-fdf4b935e06142aaba6872f4e4a0be10 |
| Source note | uspto-grants-2015_02 |