HCID 89963686, compound → HCID 89964245, compound

HRID 1844026Notes

Reaction equation

HRID 1844026 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-])=O)[C:8](=[O:15])[N:7]([C:16]1[CH:17]=[N:18][CH:19]=[CH:20][C:21]=1[CH3:22])[CH2:6][CH2:5]2>[Pd].CO>[NH2:12][C:11]1[CH:10]=[C:9]2[C:4]([CH2:5][CH2:6][N:7]([C:16]3[CH:17]=[N:18][CH:19]=[CH:20][C:21]=3[CH3:22])[C:8]2=[O:15])=[CH:3][C:2]=1[CH3:1]

Participants

4

Reactant 1

HCID 89963686HCID 89963686, compound

Product 1

HCID 89964245HCID 89964245, compoundYield 47.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

6-Methyl-2-(4-methylpyridin-3-yl)-7-nitro-3,4-dihydroisoquinolin-1(2H)-one (I-69f: 940 mg, 3.154 mmol) was reacted with 10% Pd—C (200 mg) and methanol (15 mL) to afford 400 mg of the product (36% yield). LCMS: 79.19%, m/z=268.1 (M+1)

Sources & evidence

ORD record
ord-accdc8ab09fc4367909e841624b886d6
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Reaction notes

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