Sulfuric Acid → HCID 89964173, compound

HRID 1844029Notes

Reaction equation

HRID 1844029 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([C:13]1[CH:14]=[N:15][CH:16]=[CH:17][C:18]=1[C:19]([F:22])([F:21])[F:20])[CH2:6][CH2:5]2.OS(O)(=O)=O.[N+:28]([O-])([O-:30])=[O:29].[K+]>>[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:28]([O-:30])=[O:29])[C:8](=[O:12])[N:7]([C:13]1[CH:14]=[N:15][CH:16]=[CH:17][C:18]=1[C:19]([F:20])([F:22])[F:21])[CH2:6][CH2:5]2

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 24434Potassium NitrateHCID 89964166HCID 89964166, compound

Product 1

HCID 89964173HCID 89964173, compoundYield 68%

Procedure

6-Methyl-2-(4-(trifluoromethyl)pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one (71A: 450 mg, 1.465 mmol) was reacted with concentrated H2SO4 (4.4 mL) and KNO3 (163 mg, 1.6126 mmol) for 2 hours to afford 350 mg of the product (68% yield).

Sources & evidence

ORD record
ord-c0aab4cf98c84d118713c96633ece227
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Reaction notes

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