HCID 89964745, compound → HCID 89964618, compound

HRID 1844030Notes

Reaction equation

HRID 1844030 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[N:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13]3[NH:21]N=[CH:19][C:14]=3[CH:15]=2)[C:10]1=[O:22]>CO.[Pd]>[NH2:21][C:13]1[CH:12]=[C:11]2[C:16]([CH2:17][CH2:18][N:9]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][C:3]=3[C:2]([F:24])([F:23])[F:1])[C:10]2=[O:22])=[CH:15][C:14]=1[CH3:19]

Participants

4

Reactant 1

HCID 89964745HCID 89964745, compound

Product 1

HCID 89964618HCID 89964618, compoundYield 93.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

6-Methyl-7-nitro-2-(4-(trifluoromethyl)pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one (72A: 350 mg, 1 mol) in methanol (10 mL) was reduced with 10% Pd/C (100 mg) to afford 300 mg of the product (93.7% yield).

Sources & evidence

ORD record
ord-38bc99b629c34f3ba5da9b9abec684d5
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Reaction notes

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