HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 89964745, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 89964206 | HCID 89964206 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 89964745 | HCID 89964745 | 37.6% |
Reaction Steps
1-Acetyl-7-(4-(trifluoromethyl)pyridin-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-g]isoquinolin-8(5H)-one (I-72c: 45 mg, 12 mmmol) in chloroform was deacylated with 6N HCl for 16 hours. Purification by column chromatography on silica gel (4% methanol in DCM) afforded 15 mg of the product (37.5% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-8cc43c93f72543bf948b84633b83e767 |
| Source note | uspto-grants-2015_02 |