Hydrochloric Acid → HCID 89964745, compound

HRID 1844032Notes

Reaction equation

HRID 1844032 reaction equation
C([N:4]1[C:16]2[CH:15]=[C:14]3[C:9]([CH2:10][CH2:11][N:12]([C:18]4[CH:19]=[N:20][CH:21]=[CH:22][C:23]=4[C:24]([F:27])([F:26])[F:25])[C:13]3=[O:17])=[CH:8][C:7]=2[CH:6]=[N:5]1)(=O)C.Cl>C(Cl)(Cl)Cl>[F:26][C:24]([F:25])([F:27])[C:23]1[CH:22]=[CH:21][N:20]=[CH:19][C:18]=1[N:12]1[CH2:11][CH2:10][C:9]2[C:14](=[CH:15][C:16]3[NH:4][N:5]=[CH:6][C:7]=3[CH:8]=2)[C:13]1=[O:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89964206HCID 89964206, compound

Product 1

HCID 89964745HCID 89964745, compoundYield 37.6%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1-Acetyl-7-(4-(trifluoromethyl)pyridin-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-g]isoquinolin-8(5H)-one (I-72c: 45 mg, 12 mmmol) in chloroform was deacylated with 6N HCl for 16 hours. Purification by column chromatography on silica gel (4% methanol in DCM) afforded 15 mg of the product (37.5% yield).

Workup

  1. customPurification by column chromatography on silica gel (4% methanol in DCM)

Sources & evidence

ORD record
ord-8cc43c93f72543bf948b84633b83e767
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Reaction notes

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