1,4-Dioxane → 2-(4-cyclopropylpyridin-3-yl)-7-(trifluoromethyl)-3,4-dihydroisoquinolin-1(2H)-one

HRID 1844036Notes

Reaction equation

[F:1][C:2]([F:15])([F:14])[C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][NH:9][C:10]2=[O:13])=[CH:5][CH:4]=1.[CH:16]1([C:19]2[CH:24]=[CH:23][N:22]=[CH:21][C:20]=2I)[CH2:18][CH2:17]1.O1CCOCC1.P([O-])([O-])([O-])=O.[K+].[K+].[K+]>C(Cl)(Cl)Cl.[Cu](I)I.CO>[CH:16]1([C:19]2[CH:24]=[CH:23][N:22]=[CH:21][C:20]=2[N:9]2[CH2:8][CH2:7][C:6]3[C:11](=[CH:12][C:3]([C:2]([F:1])([F:14])[F:15])=[CH:4][CH:5]=3)[C:10]2=[O:13])[CH2:18][CH2:17]1

Participants

Conditions

Temperature: 120 °C

Procedure

7-(trifluoromethyl)-3,4-dihydroisoquinolin-1(2H)-one (I-4-d: 100 mg, 0.465 mmol) was reacted with 4-cyclopropyl-3-iodopyridine (I-73c: 125.3 mg, 0.51 mmol), 1,4-dioxane (5 mL), copper iodide (8.8 mg, 0.0465 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (6.6 mg, 0.0465 mmol) and potassium phosphate (246 mg, 1.16 mmol). The resulting mixture was stirred for 24 hours at 120° C. The reaction was monitored by TLC (10% methanol in CHCl3). The reaction mixture was concentrated to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCl3), followed by preparative HPLC afforded 20 mg of the product (12.9% yield).

Workup

concentrationThe reaction mixture was concentrated
customto afford the crude product
customPurification by column chromatography on silica gel (2% methanol in CHCl3)

Sources & evidence

ORD record: ord-fb71b6cd3f614efd9c5ebf1f070b470d
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08946260B2

Reaction notes

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