Sulfuric Acid → HCID 66801954, compound

HRID 1844057Notes

Reaction equation

HRID 1844057 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([C:13]1[CH:14]=[N:15][CH:16]=[CH:17][C:18]=1[CH3:19])[CH2:6][CH2:5]2.OS(O)(=O)=O.[N+:25]([O-])([O-:27])=[O:26].[K+]>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:25]([O-:27])=[O:26])[C:8](=[O:12])[N:7]([C:13]1[CH:14]=[N:15][CH:16]=[CH:17][C:18]=1[CH3:19])[CH2:6][CH2:5]2

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 24434Potassium NitrateHCID 66802002HCID 66802002, compound

Product 1

HCID 66801954HCID 66801954, compoundYield 60.1%

Procedure

6-Fluoro-2-(4-methylpyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one (83A: 350 mg, 1.38 mmol) was reacted with conc. H2SO4 (4 mL) and KNO3 (154 mg, 1.52 mmol) for 4 hours to afford 250 mg of the product (60.0% yield).

Sources & evidence

ORD record
ord-87b2676269674731845de53da20d3ef7
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Reaction notes

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