Chlorosulfonic acid → HCID 66803491, compound

HRID 1844061Notes

Reaction equation

HRID 1844061 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:12][CH2:13][C:14]([OH:16])=O)[CH:5]=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].ClS(O)(=O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[C:8]([F:9])([F:10])[F:11])[C:14](=[O:16])[CH2:13][CH2:12]2

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 57368010HCID 57368010, compound

Product 1

HCID 66803491HCID 66803491, compoundYield 70%

Procedure

3-(3-Chloro-4-(trifluoromethyl)phenyl)propanoic acid (I-85c: 1.0 g, 3.96 mmol) was reacted with chlorosulfonic acid (12.6 mL) for 5 hours at 0° C. Purification by column chromatography on silica gel (10% ethyl acetate in hexane) afforded 650 mg of the product 69.8% yield).

Workup

  1. customPurification by column chromatography on silica gel (10% ethyl acetate in hexane)

Sources & evidence

ORD record
ord-82fb97b6d24b409a868f1070ea05dc3b
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Reaction notes

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