HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosulfonic acid → HCID 66803491, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosulfonic acid | HCID 24638 | — |
| Reactant | HCID 57368010 | HCID 57368010 | — |
| Product | HCID 66803491 | HCID 66803491 | 70% |
Reaction Steps
3-(3-Chloro-4-(trifluoromethyl)phenyl)propanoic acid (I-85c: 1.0 g, 3.96 mmol) was reacted with chlorosulfonic acid (12.6 mL) for 5 hours at 0° C. Purification by column chromatography on silica gel (10% ethyl acetate in hexane) afforded 650 mg of the product 69.8% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946260B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-82fb97b6d24b409a868f1070ea05dc3b |
| Source note | uspto-grants-2015_02 |