Hydrochloric Acid → HCID 67975417, compound

Participants

Reaction Steps

To a solution of 3-[1-dimethylamino-meth-(Z)-ylidene]-2-oxo-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]pyrrole-1-carboxylic acid tert-butyl ester D1 (1.68 g, 4.63 mmol) in dioxane (50 mL) was added HCl (37%, 8.37 mL). The solution was stirred overnight at room temperature and was then diluted with water, extracted with ethyl acetate, washed with brine, dried and concentrated to give 3-[1-Hydroxy-meth-(Z)-ylidene]-3,3a,4,8b-tetrahydro-1H-indeno[1,2-b]pyrrol-2-one C1 identical to method A (0.85 g, 78%).

Provenance & Evidence