Hydrochloric Acid → HCID 67975417, compound

HRID 1844099Notes

Reaction equation

HRID 1844099 reaction equation
C(OC([N:8]1[C:12](=[O:13])/[C:11](=[CH:14]\N(C)C)/[CH:10]2[CH2:18][C:19]3[C:24]([CH:9]12)=[CH:23][CH:22]=[CH:21][CH:20]=3)=O)(C)(C)C.Cl.[O:26]1CCOCC1>O>[OH:26]/[CH:14]=[C:11]1/[CH:10]2[CH2:18][C:19]3[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:9]2[NH:8][C:12]/1=[O:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67975561HCID 67975561, compound

Product 1

HCID 67975417HCID 67975417, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 3-[1-dimethylamino-meth-(Z)-ylidene]-2-oxo-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]pyrrole-1-carboxylic acid tert-butyl ester D1 (1.68 g, 4.63 mmol) in dioxane (50 mL) was added HCl (37%, 8.37 mL). The solution was stirred overnight at room temperature and was then diluted with water, extracted with ethyl acetate, washed with brine, dried and concentrated to give 3-[1-Hydroxy-meth-(Z)-ylidene]-3,3a,4,8b-tetrahydro-1H-indeno[1,2-b]pyrrol-2-one C1 identical to method A (0.85 g, 78%).

Workup

  1. extractionextracted with ethyl acetate
  2. washwashed with brine
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-df8b2b1e4bdf42b6874e90a0cd8b676c
Source dataset
uspto-grants-2015_02
Patent number
US08946280B2

Reaction notes

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