HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 4-Methoxybenzoyl isocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Methoxybenzamide | HCID 76959 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Methoxybenzoyl isocyanate | HCID 12551097 | — |
Reaction Steps
To 4-methoxybenzamide (2.6 mmol) in dichloromethane (10 mL) was added oxalyl chloride 98% (6.61 mmol) dropwise. The mixture was heated to reflux for 20 h. Reaction completion monitored by TLC. The solvent was removed in vacuo (40° C., 760 mmHg) to obtain title compound D11, which was immediately used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946282B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-60b3d5dd1f9f44979c3b59744d782027 |
| Source note | uspto-grants-2015_02 |