Trifluoroacetic acid → HCID 86697426, compound

HRID 1844338Notes

Reaction equation

HRID 1844338 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][N:5]2[CH:10]=[CH:9][C:8]([NH:11][CH2:12][CH2:13][N:14](C)[C:15](=O)OC(C)(C)C)=[N:7][C:6]=12.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[N:4][N:5]2[CH:10]=[CH:9][C:8]([NH:11][CH2:12][CH2:13][NH:14][CH3:15])=[N:7][C:6]=12

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86697425HCID 86697425, compound

Product 1

HCID 86697426HCID 86697426, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The tert-butoxycarbonyl was removed by dissolving 600 mg (1.62 mmol) of tert-butyl (2-((3-bromopyrazolo[1,5-a]pyrimidin-5-yl)amino)ethyl)(methyl)carbamate in 4 mL of DCM, and then adding 4 mL TFA, stirring for 0.5 hr at rt, and concentrating the mixture to afford the TFA-salt of the desired product in 100% yield (622 mg).

Workup

  1. customThe tert-butoxycarbonyl was removed
  2. concentrationconcentrating the mixture

Sources & evidence

ORD record
ord-c74e941464824f8ca4e8276f7db667f1
Source dataset
uspto-grants-2015_02
Patent number
US08946415B2

Reaction notes

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