Tetrahydro-4H-pyran-4-ol → Tetrahydro-2H-pyran-4-yl 4-(3-bromopyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

HRID 1844368Notes

Reaction equation

HRID 1844368 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([OH:7])[CH2:3][CH2:2]1.[Br:8][C:9]1[CH:10]=[N:11][N:12]2[CH:17]=[CH:16][C:15]([N:18]3[CH2:23][CH2:22][N:21]([C:24](O[C@@H]4CCOC4)=[O:25])[CH2:20][CH2:19]3)=[N:14][C:13]=12>>[Br:8][C:9]1[CH:10]=[N:11][N:12]2[CH:17]=[CH:16][C:15]([N:18]3[CH2:23][CH2:22][N:21]([C:24]([O:7][CH:4]4[CH2:5][CH2:6][O:1][CH2:2][CH2:3]4)=[O:25])[CH2:20][CH2:19]3)=[N:14][C:13]=12

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 86697452(R)-tetrahydrofuran-3-yl 4-(3-bromopyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

Product 1

HCID 86697454Tetrahydro-2H-pyran-4-yl 4-(3-bromopyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

Procedure

This was made by using tetrahydro-2H-pyran-4-ol and following the Part B in the procedure described above for making (R)-tetrahydrofuran-3-yl 4-(3-bromopyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate.

Sources & evidence

ORD record
ord-7d0a9abfee4247509576e4bc2286944f
Source dataset
uspto-grants-2015_02
Patent number
US08946415B2

Reaction notes

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