Diglyme → 4-(Methoxymethyl)-N-phenyl-1-[2-(2-thienyl)ethyl]-4-piperidinamine

HRID 1844430Notes

Reaction equation

HRID 1844430 reaction equation
[C:1]1([NH:7][C:8]2([CH2:21][OH:22])[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]3[S:17][CH:18]=[CH:19][CH:20]=3)[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:23]OCCOCCOC>>[CH3:23][O:22][CH2:21][C:8]1([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 8150DiglymeHCID 10881633[4-(phenylamino)-1-[2-(thiophen-2-yl)ethyl]piperidin-4-yl]methanol

Product 1

HCID 152954984-(Methoxymethyl)-N-phenyl-1-[2-(2-thienyl)ethyl]-4-piperidinamine

Procedure

Residual alcohol (2), diglyme and mineral oil are reduced/eliminated by either of the following methods:

Sources & evidence

ORD record
ord-bc213d94ca23475a9759cbcf076bd8be
Source dataset
uspto-grants-2015_02
Patent number
US08946433B2

Reaction notes

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