Pyrrolidine → 2-Methyl-4-(pyrrolidine-4-carbonyl)-2H-pyrazole-3-carboxylic acid (2-diethylamino-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-amide

HRID 1844473Notes

Reaction equation

HRID 1844473 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:6]([N:8]([CH2:30][CH3:31])[C:9]1[N:29]=[C:12]2[CH:13]=[CH:14][C:15]([NH:17][C:18]([C:20]3[N:24]([CH3:25])[N:23]=[CH:22][C:21]=3[C:26](O)=[O:27])=[O:19])=[CH:16][N:11]2[N:10]=1)[CH3:7]>>[CH2:30]([N:8]([CH2:6][CH3:7])[C:9]1[N:29]=[C:12]2[CH:13]=[CH:14][C:15]([NH:17][C:18]([C:20]3[N:24]([CH3:25])[N:23]=[CH:22][C:21]=3[C:26]([CH:4]3[CH2:5][NH:1][CH2:2][CH2:3]3)=[O:27])=[O:19])=[CH:16][N:11]2[N:10]=1)[CH3:31]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 894634545-(2-Diethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Product 1

HCID 1317324232-Methyl-4-(pyrrolidine-4-carbonyl)-2H-pyrazole-3-carboxylic acid (2-diethylamino-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-amide

Procedure

Using pyrrolidine and 5-(2-diethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. White solid (60 mg, 75%). MS: m/z=411 (M+H+).

Sources & evidence

ORD record
ord-d92b2646c1274304b11ab76b5a6b398b
Source dataset
uspto-grants-2015_02
Patent number
US08946427B2

Reaction notes

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