Hydrochloric Acid → HCID 56952845, compound

HRID 1844518Notes

Reaction equation

HRID 1844518 reaction equation
[F:1][C:2]1[C:25]([F:26])=[C:24]([F:27])[CH:23]=[CH:22][C:3]=1[C:4]([NH:6][C:7]1[CH:8]=[N:9][C:10]([O:13][C:14]2[CH:19]=[CH:18][C:17]([NH:20][CH3:21])=[CH:16][CH:15]=2)=[CH:11][CH:12]=1)=[O:5].[ClH:28]>CCO>[ClH:28].[F:1][C:2]1[C:25]([F:26])=[C:24]([F:27])[CH:23]=[CH:22][C:3]=1[C:4]([NH:6][C:7]1[CH:8]=[N:9][C:10]([O:13][C:14]2[CH:15]=[CH:16][C:17]([NH:20][CH3:21])=[CH:18][CH:19]=2)=[CH:11][CH:12]=1)=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56952649HCID 56952649, compound

Product 1

HCID 56952845HCID 56952845, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To an EtOH (10 mL) solution of 2,3,4-trifluoro-N-{6-[4-(methylamino)phenoxy]pyridin-3-yl}benzamide (0.55 g) was added 6 M HCl (0.27 mL) at room temperature. The resultant mixture was stirred at room temperature. The resulting precipitate was collected by filtration to give the title compound as a white powder (0.35 g).

Workup

  1. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-87fc229db8744f71806c1cb8daec024b
Source dataset
uspto-grants-2015_02
Patent number
US08946437B2

Reaction notes

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