Thionyl Chloride → HCID 86664521, compound

HRID 1844596Notes

Reaction equation

HRID 1844596 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([Cl:19])[C:17]=1[CH3:18])[C:12](O)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:22])=O>C(#N)C>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([Cl:19])[C:17]=1[CH3:18])[C:12]([Cl:22])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 67217646HCID 67217646, compound

Product 1

HCID 86664521HCID 86664521, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

350 mg 3-benzyloxy-5-chloro-4-methyl-benzoic acid in 10 ml acetonitrile are combined with 0.60 ml thionylchloride and gently refluxed for 15 minutes. Then the reaction mixture is evaporated down and evaporated again with toluene. The acid chloride is further reacted without any further purification.

Workup

  1. temperaturegently refluxed for 15 minutes
  2. customThen the reaction mixture is evaporated down
  3. customevaporated again with toluene
  4. customThe acid chloride is further reacted without any further purification

Sources & evidence

ORD record
ord-24ee449512e54bac8ab18a0d55756573
Source dataset
uspto-grants-2015_02
Patent number
US08946438B2

Reaction notes

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