Potassium Cyanide → HCID 68299240, compound

Participants

Reaction Steps

1-Methoxy-piperidine-4-carbaldehyde (2.86 g, 20 mmol) was added to a mixture of KCN (1.95 g, 30 mmol) and NH4Cl (2.2 g, 41 mmol) in H2O (20 ml) and NH3.H2O (20 ml). The mixture was stirred at room temperature for 12 h and then was extracted with CH2Cl2 (5×50 ml). The combined organic layers were dried with Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by chromatography on silica gel. Yield: 2.0 g of amino-(1-methoxy-piperidin-4-yl)-acetonitrile as an oil.

Provenance & Evidence