Potassium Cyanide → HCID 68299240, compound

HRID 1844675Notes

Reaction equation

HRID 1844675 reaction equation
[CH3:1][O:2][N:3]1[CH2:8][CH2:7][CH:6]([CH:9]=O)[CH2:5][CH2:4]1.[C-:11]#[N:12].[K+].[NH4+:14].[Cl-]>O.N.O>[NH2:14][CH:9]([CH:6]1[CH2:7][CH2:8][N:3]([O:2][CH3:1])[CH2:4][CH2:5]1)[C:11]#[N:12]

Participants

6

Reactant 3

HCID 9032Potassium CyanideHCID 25517Ammonium ChlorideHCID 86707845HCID 86707845, compound

Product 1

HCID 68299240HCID 68299240, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 12896473Azane;hydrateSolvent

Procedure

1-Methoxy-piperidine-4-carbaldehyde (2.86 g, 20 mmol) was added to a mixture of KCN (1.95 g, 30 mmol) and NH4Cl (2.2 g, 41 mmol) in H2O (20 ml) and NH3.H2O (20 ml). The mixture was stirred at room temperature for 12 h and then was extracted with CH2Cl2 (5×50 ml). The combined organic layers were dried with Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by chromatography on silica gel. Yield: 2.0 g of amino-(1-methoxy-piperidin-4-yl)-acetonitrile as an oil.

Workup

  1. extractionwas extracted with CH2Cl2 (5×50 ml)
  2. dry with materialThe combined organic layers were dried with Na2SO4
  3. filtrationfiltered
  4. customevaporated under reduced pressure
  5. customThe residue was purified by chromatography on silica gel

Sources & evidence

ORD record
ord-7e1b60c925f040aba87fa5f8d736b925
Source dataset
uspto-grants-2015_02
Patent number
US08946453B2

Reaction notes

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