反应详情

To a solution of 1,3-dibromo-5-tert-butylbenzene (404 mg) in dry THF (10 mL) was added n-BuLi (0.84 mL) at −78° C. and after 20 min, acetone was added dropwise to the above solution at −78° C. and the mixture was stirred at this temperature for 30 min and at rt for 1 h, diluted with sat. NH4Cl and extracted with EA (3×30 mL). The organic layer was dried over Na2SO4, evaporated and purified by CC to give compound P23a (380 mg, 70%) as a white solid.

1. extractionextracted with EA (3×30 mL)
2. dry with materialThe organic layer was dried over Na2SO4
3. customevaporated
4. custompurified by CC
5. customto give compound P23a (380 mg, 70%) as a white solid