Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,3-Dibromo-5-(trifluoromethyl)benzene | HCID 2063489 | — |
| Reactant | (Prop-1-en-2-yl)boronic acid | HCID 10855372 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86719127 | HCID 86719127 | — |
Reaction Steps
To a solution of 1,3-dibromo-5-(trifluoromethyl)benzene (3.03 g, 10 mmol) in dioxane (20 mL) was added Pd(PPh3)4 (300 mg, 0.26 mmol), prop-1-en-2-ylboronic acid (1.0 g, 12 mmol), K2CO3 (2.8 g, 20 mmol) and water (1 mL) under N2. The mixture was stirred at 90° C. overnight, concentrated and purified by CC (hexane) to afford compound P28a (1.9 g, 71%) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08946446B2 |
|---|
| Source dataset | uspto-grants-2015_02 |
|---|
| ORD ID | ord-19a71ce63fca43b8a044e083dc6b40b5 |
|---|
| Source note | uspto-grants-2015_02 |
|---|
