5-(3,5-Di-tert-butylphenyl)-2-methyl-1-(piperidin-1-ylsulfonyl)-1H-pyrrole-3-carboxylic acid → 1-((2-(3,5-Di-tert-butylphenyl)-5-methyl-1H-pyrrol-1-yl)sulfonyl)piperidine

Participants

Reaction Steps

A solution of compound 4d (700 mg, 1.5 mmol) in TFA (5 mL) was heated to 100° C. for 30 min, evaporated and redissolved in EA, washed with aq. NaHCO3 (3×50 mL) and brine, dried with Na2SO4, concentrated and purified by CC (PE/EA=1/0 to 7/1) to get compound 4e (260 mg, 41%).

Provenance & Evidence