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HRID1844716

反应详情

EQUATION

反应方程式

HRID 1844716 的结构方程式

REACTANTS

反应物

1
结构：Cc1c(C(=O)O)cc(-c2cc(C(C)(C)C)cc(C(C)(C)C)c2)n1S(=O)(=O)N1CCCCC1
HCID70872790

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc(-c2cc(C(C)(C)C)cc(C(C)(C)C)c2)n1S(=O)(=O)N1CCCCC1
HCID86719132

未命名化合物

收率 41.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=C(O)C(F)(F)F
溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

A solution of compound 4d (700 mg, 1.5 mmol) in TFA (5 mL) was heated to 100° C. for 30 min, evaporated and redissolved in EA, washed with aq. NaHCO3 (3×50 mL) and brine, dried with Na2SO4, concentrated and purified by CC (PE/EA=1/0 to 7/1) to get compound 4e (260 mg, 41%).

WORKUP

后处理

  1. customevaporated
  2. dissolutionredissolved in EA
  3. washwashed with aq. NaHCO3 (3×50 mL) and brine
  4. dry with materialdried with Na2SO4
  5. concentrationconcentrated
  6. custompurified by CC (PE/EA=1/0 to 7/1)