HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1844736Generated: October 31, 2026
Chlorosulfonic acid → 5-(Cyclohexanecarbonyl)-1-methyl-1H-pyrrole-2-sulfonyl chloride
https://huagongshe.com/reaction/1844736
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorosulfonic acid | HCID 24638 | — |
| Reactant | Cyclohexyl(1-methyl-1H-pyrrol-2-yl)methanone | HCID 14043405 | — |
| Product | 5-(Cyclohexanecarbonyl)-1-methyl-1H-pyrrole-2-sulfonyl chloride | HCID 82375151 | 80% |
Reaction Steps
To a solution of compound 25b (1.0 g, 5.2 mmol) was added portionwise chlorosulfonic acid (5 mL, 75 mmol) at 0° C., heated to 60° C. for 2 h, poured carefully into ice-water and extracted with CHCl3. The organic phase was dried (MgSO4), evaporated and purified by CC to give compound 25c (1.2 g, 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08946446B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-e63c9eadc5244481ae63e8b3dca8fb7a |
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| Source note | uspto-grants-2015_02 |
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