反应详情

To a stirred mixture of compound 27e (280 mg, 0.94 mmol) in dry THF (3 mL) was added NBS (200 mg, 1.13 mmol) at −78° C. and the solution was stirred at this temperature for 30 min, quenched with water and extracted with EA twice. The combined organic layers were washed with water (3×) and brine, concentrated and purified by CC (PE/EA=5/1) to give compound 27f (300 mg, 85%) as an oil.

1. customquenched with water
2. extractionextracted with EA twice
3. washThe combined organic layers were washed with water (3×) and brine
4. concentrationconcentrated
5. custompurified by CC (PE/EA=5/1)