Calcium Carbonate → L-(-)-Ornithine

Participants

Reaction Steps

1 part L-ornithine hydrochloride by mole was suspended in about 10.6 parts ethanol. Subsequently, the reaction mass (suspension) was heated to about 50° C. and about 1 part calcium carbonate was added. The reaction mass was stirred for about 2 hours. The free L-ornithine base was isolated by filtration to obtain a powder, while the CaCl2 remained in solution. The filtered powder was dissolved in water and filtered to remove unreacted calcium carbonate. About 1 part phenyl acetic acid by mole in isopropanol was intermixed with the aqueous L-ornithine solution. The final product precipitated from solution and was isolated, washed, and dried. Yield: 44.5%.

Provenance & Evidence