Calcium Carbonate → L-(-)-Ornithine

HRID 1844763Notes

Reaction equation

HRID 1844763 reaction equation
Cl.[NH2:2][C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][CH2:5][CH2:6][NH2:7].C(=O)([O-])[O-].[Ca+2]>C(O)C>[NH2:2][C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][CH2:5][CH2:6][NH2:7]

Participants

4

Reactant 2

HCID 10112Calcium CarbonateHCID 76654Ornithine hydrochloride

Product 1

HCID 6262L-(-)-OrnithineYield 44.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 part L-ornithine hydrochloride by mole was suspended in about 10.6 parts ethanol. Subsequently, the reaction mass (suspension) was heated to about 50° C. and about 1 part calcium carbonate was added. The reaction mass was stirred for about 2 hours. The free L-ornithine base was isolated by filtration to obtain a powder, while the CaCl2 remained in solution. The filtered powder was dissolved in water and filtered to remove unreacted calcium carbonate. About 1 part phenyl acetic acid by mole in isopropanol was intermixed with the aqueous L-ornithine solution. The final product precipitated from solution and was isolated, washed, and dried. Yield: 44.5%.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-29ee2e1db6354f2b9387e8b5321bcfbb
Source dataset
uspto-grants-2015_02
Patent number
US08946473B2

Reaction notes

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