反应详情

To a cold solution (5° C.) of 3.36 g of Intermediate 5, benzylamide in 40 mL of dichloromethane was added 6.02 mL of 36% HCl. The reaction mixture was stirred at room temperature until no starting material was observed by TLC. The organic phase was washed with 1N HCl (2×30 mL) and the combined aqueous phase basified to 10-12 with 25% NaOH. After saturating the aqueous phase with sodium chloride, it was extracted with dichloromethane (3×30 mL). The organic phase was dried and concentrated under vacuum yielding 2.01 g of a pale yellow oil.

1. washThe organic phase was washed with 1N HCl (2×30 mL)
2. concentrationAfter saturating the aqueous phase with sodium chloride, it
3. extractionwas extracted with dichloromethane (3×30 mL)
4. customThe organic phase was dried
5. concentrationconcentrated under vacuum