反应详情

To a cold solution (−2° C.) of 1.94 g of Intermediate 6, in 40 mL of dichloromethane was added dropwise 2.12 g of acetic anhydride maintaining the temperature below 5° C. The reaction mixture was stirred at room temperature for 3 hours and the organic phase was washed with water (2×20 mL), sodium bicarbonate solution (2×20 mL), brine and dried over sodium sulfate. The solvent was removed under vacuum and a white solid was obtained. The product was dissolved in 20 mL of ethyl acetate at reflux temperature and cooled slowly to 0° C. The solid was collected by filtration and dried yielding 1.6 g of lacosamide as a white solid.

1. washthe organic phase was washed with water (2×20 mL), sodium bicarbonate solution (2×20 mL), brine
2. dry with materialdried over sodium sulfate
3. customThe solvent was removed under vacuum
4. customa white solid was obtained
5. temperatureat reflux temperature
6. temperaturecooled slowly to 0° C
7. filtrationThe solid was collected by filtration
8. customdried