Citric Acid → HCID 86662969, compound

HRID 1844793Notes

Reaction equation

HRID 1844793 reaction equation
[CH:1]#[C:2][CH2:3][NH:4][C@H:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH2:7][CH2:6]1.[C:14]([OH:26])(=[O:25])[CH2:15][C:16]([CH2:21][C:22]([OH:24])=[O:23])([C:18]([OH:20])=[O:19])[OH:17]>CC(C)=O>[CH:1]#[C:2][CH2:3][NH:4][C@H:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH2:7][CH2:6]1.[C:14]([O-:26])(=[O:25])[CH2:15][C:16]([CH2:21][C:22]([O-:24])=[O:23])([C:18]([O-:20])=[O:19])[OH:17]

Participants

4

Reactant 2

HCID 311Citric AcidHCID 3052776Rasagiline

Product 1

HCID 86662969HCID 86662969, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

To a solution of 100 mg (0.58 mmol) rasagiline in 1 ml acetone a solution of 117 mg (0.61 mmol, 1.05 eq) anhydrous citric acid in 1 ml warm acetone was added. The solution became turbid during addition forming a waxy precipitate. The supernatant was removed and the wax was washed with 2 ml acetone twice using sonication. On drying in high vacuum a white solid foam was obtained. Drying was continued for 6 h on high vacuum (120 mg, 0.33 mmol, 57%).

Workup

  1. additionwas added
  2. additionduring addition
  3. customforming a waxy precipitate
  4. customThe supernatant was removed
  5. washthe wax was washed with 2 ml acetone
  6. customsonication
  7. customOn drying in high vacuum a white solid foam
  8. customwas obtained
  9. customDrying

Sources & evidence

ORD record
ord-bb1dfe1fd84d4f1389ea6851e1a45299
Source dataset
uspto-grants-2015_02
Patent number
US08946482B2

Reaction notes

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