Propionic Acid → HCID 86666376, compound

HRID 1844796Notes

Reaction equation

HRID 1844796 reaction equation
[C:1]([OH:5])(=[O:4])[CH2:2][CH3:3].[CH:6]#[C:7][CH2:8][NH:9][C@H:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[CH2:12][CH2:11]1>C(OC(C)C)(C)C>[CH:6]#[C:7][CH2:8][NH:9][C@H:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[CH2:12][CH2:11]1.[C:1]([O-:5])(=[O:4])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 1032Propionic AcidHCID 3052776Rasagiline

Product 1

HCID 86666376HCID 86666376, compound

Reagents, catalysts & solvents 1

HCID 7914Diisopropyl EtherSolvent2×

Procedure

To a solution of 43 mg (0.58 mmol, 1.0 eq) propionic acid in 0.5 ml diisopropyl ether a solution of 100 mg (0.58 mmol) rasagiline in 0.5 ml diisopropyl ether was added. After stirring for 90 min the solvent was removed in vacuo. The residue was dried in high vacuum for 5 h to yield a thick oil (143 mg, 0.58 mmol, quant.).

Workup

  1. customwas removed in vacuo
  2. customThe residue was dried in high vacuum for 5 h
  3. customto yield a thick oil (143 mg, 0.58 mmol, quant.)

Sources & evidence

ORD record
ord-83da09e0befe41a0b53168175a524442
Source dataset
uspto-grants-2015_02
Patent number
US08946482B2

Reaction notes

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