HCID 58724480, compound → HCID 58724484, compound

HRID 1844991Notes

Reaction equation

HRID 1844991 reaction equation
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:18](=[O:37])[NH:19][C:20]3[NH:24][C:23]4[CH:25]=[CH:26][CH:27]=[C:28]([C:29](=[O:36])[NH:30][C:31]5[NH:32][CH:33]=[CH:34][N:35]=5)[C:22]=4[N:21]=3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[NH:32]1[CH:33]=[CH:34][N:35]=[C:31]1[NH:30][C:29]([C:28]1[C:22]2[N:21]=[C:20]([NH:19][C:18]([C:13]3[CH:14]=[C:15]4[C:10](=[CH:11][CH:12]=3)[CH2:9][NH:8][CH2:17][CH2:16]4)=[O:37])[NH:24][C:23]=2[CH:25]=[CH:26][CH:27]=1)=[O:36]

Participants

4

Reactant 1

HCID 58724480HCID 58724480, compound

Product 1

HCID 58724484HCID 58724484, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

49.8 mg (0.10 mmol) of 6-[4-(1H-imidazol-2-ylcarbamoyl)-1H-benzoimidazol-2-ylcarbamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester in 2 mL of 4 N HCl in dioxane was stirred at r.t. for 2 h. Evaporation of solvents in vacuo gave 1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid [4-(1H-imidazol-2-ylcarbamoyl)-1H-benzoimidazol-2-yl]-amide in quantitative yield. LCMS: 402 (M+1)+.

Workup

  1. customEvaporation of solvents in vacuo

Sources & evidence

ORD record
ord-ab0ef7e5804d4456807adb06e14b49eb
Source dataset
uspto-grants-2015_02
Patent number
US08946259B2

Reaction notes

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