Ammonium Hydroxide → HCID 86608394, compound

HRID 1845084Notes

Reaction equation

[N+:1]([C:4]1[C:12](F)=[C:11]([F:14])[C:10]([F:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-:3])=[O:2].[OH-].[NH4+:17]>>[NH2:17][C:12]1[C:4]([N+:1]([O-:3])=[O:2])=[C:5]([CH:9]=[C:10]([F:15])[C:11]=1[F:14])[C:6]([OH:8])=[O:7]

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 18929901HCID 18929901, compound

Product 1

HCID 86608394HCID 86608394, compound

Procedure

1.4 g (6.3 mmol) of 2-nitro-3,4,5-trifluoro-benzoic acid was treated with ammonium hydroxide to produce 3-amino-4,5-difluoro-2-nitro-benzoic acid. LCMS: 219 (M+1)+. 1.2 g (5.5 mmol) of 3-amino-4,5-difluoro-2-nitro-benzoic acid was heated with excess 21% NaOEt in ethanol at 90° C. for 6 h to yield 3-amino-5-ethoxy-4-fluoro-2-nitro-benzoic acid. LCMS: 245 (M+1)+.

Sources & evidence

ORD record: ord-25958d8862d0494a904cd31e9b85c371
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08946259B2

Reaction notes

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