Sodium ethoxide → HCID 86608395, compound

HRID 1845085Notes

Reaction equation

HRID 1845085 reaction equation
[NH2:1][C:2]1[C:3]([N+:13]([O-:15])=[O:14])=[C:4]([CH:8]=[C:9](F)[C:10]=1[F:11])[C:5]([OH:7])=[O:6].[CH3:16][CH2:17][O-:18].[Na+]>C(O)C>[NH2:1][C:2]1[C:3]([N+:13]([O-:15])=[O:14])=[C:4]([CH:8]=[C:9]([O:18][CH2:17][CH3:16])[C:10]=1[F:11])[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 86608394HCID 86608394, compound

Product 1

HCID 86608395HCID 86608395, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.4 g (6.3 mmol) of 2-nitro-3,4,5-trifluoro-benzoic acid was treated with ammonium hydroxide to produce 3-amino-4,5-difluoro-2-nitro-benzoic acid. LCMS: 219 (M+1)+. 1.2 g (5.5 mmol) of 3-amino-4,5-difluoro-2-nitro-benzoic acid was heated with excess 21% NaOEt in ethanol at 90° C. for 6 h to yield 3-amino-5-ethoxy-4-fluoro-2-nitro-benzoic acid. LCMS: 245 (M+1)+.

Sources & evidence

ORD record
ord-623e8ac061df43dca180029e4160eb32
Source dataset
uspto-grants-2015_02
Patent number
US08946259B2

Reaction notes

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