Triethylamine → Ethyl 4'-methyl-5-(pyrrolidine-1-carbonyl)biphenyl-3-carboxylate

Participants

Reaction Steps

To a stirred solution of ethyl 5-(chlorocarbonyl)-4′-methylbiphenyl-3-carboxylate (5.5 g, 18 mmol) in methylene chloride (100 mL) at 0° C. were slowly added pyrrolidine (2.6 g, 36 mmol) and triethylamine (7.6 mL, 54 mmol). The mixture was stirred at room temperature for 2 h, and then washed with brine, aq. Na2CO3 solution and water. The separated organic phase was dried (Na2SO4), and concentrated. The residue was purified by silica gel column (30-100% EtOAc/hexane) to afford the desired compound.

Provenance & Evidence