反应详情

To a stirred solution of ethyl 5-(chlorocarbonyl)-4′-methylbiphenyl-3-carboxylate (5.5 g, 18 mmol) in methylene chloride (100 mL) at 0° C. were slowly added pyrrolidine (2.6 g, 36 mmol) and triethylamine (7.6 mL, 54 mmol). The mixture was stirred at room temperature for 2 h, and then washed with brine, aq. Na2CO3 solution and water. The separated organic phase was dried (Na2SO4), and concentrated. The residue was purified by silica gel column (30-100% EtOAc/hexane) to afford the desired compound.

1. customat 0° C.
2. washwashed with brine, aq. Na2CO3 solution and water
3. dry with materialThe separated organic phase was dried (Na2SO4)
4. concentrationconcentrated
5. customThe residue was purified by silica gel column (30-100% EtOAc/hexane)