反应详情

To dry diethyl ether (10 mL) containing Mg turnings (0.24 g; 10 mmol) under N2 was added 1-bromo-2-methoxy-nonyl benzene (3.1 g; 10 mmol). 1,2-Dioiodoethane was added to initiate the reaction. Solid dry Ice (excess) was added after stirring for 1 hour and after additional stirring for 1 hour was added sat. NH4Cl (aq.; 20 mL) and then 4 M HCl (aq.; 2 mL). The organic phase was isolated, dried (MgSO4), filtered and purified by column chromatography (SiO2; EtOAc/PE80-100° C.=1:5) to yield 600 mg (20%) pure product.

1. addition1,2-Dioiodoethane was added
2. customthe reaction
3. stirringafter additional stirring for 1 hour
4. customThe organic phase was isolated
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. custompurified by column chromatography (SiO2; EtOAc/PE80-100° C.=1:5)