反应详情

温度

-10 °C

A solution of 2-methoxy-4-nonyl benzoic acid (600 mg; 2.15 mmol) was refluxed overnight in 6 M HCl [50% (w/w) EtOH/H2O; 35 mL). The reaction mixture was extracted with EtOAc (3×) dried (MgSO4), filtered and evaporated to dryness. The crude ester was dissolved in CH2Cl2 (10 mL), cooled to −10° C. and then added 1 M BBr3 (CH2Cl2; 10 mL; 10 mmol). The reaction mixture was allowed to warm to room temperature overnight and then poured onto H2O. Succeeding extraction with EtOAc, drying (MgSO4), filtering, evaporation to dryness and column chromatography (SiO2) yielded 130 mg (23%) product. Mp. 94-97° C.

1. extractionThe reaction mixture was extracted with EtOAc (3×)
2. dry with materialdried (MgSO4)
3. filtrationfiltered
4. customevaporated to dryness
5. dissolutionThe crude ester was dissolved in CH2Cl2 (10 mL)
6. temperatureto warm to room temperature overnight
7. additionpoured onto H2O
8. extractionextraction with EtOAc
9. dry with materialdrying (MgSO4)
10. filtrationfiltering
11. customevaporation to dryness and column chromatography (SiO2)