反应详情

温度

50 °C

Into a 20 mL reaction vessel were combined methyl 3-bromo-5-(oxiran-2-yl)benzoate (0.10 g, 0.39 mmol), ethanol (10 mL), and diethylamine (120 μL, 1.2 mmol). The mixture was heated at 50° C. overnight, and then concentrated. The residue was purified by preparative HPLC (100×21.2 mm C18 column, CH3CN/water[10 mM Et2NH]) to afford the title compound.

1. customInto a 20 mL reaction vessel
2. concentrationconcentrated
3. customThe residue was purified by preparative HPLC (100×21.2 mm C18 column, CH3CN/water[10 mM Et2NH])