Hydrochloric Acid → HCID 57826527, compound

HRID 1845348Notes

Reaction equation

HRID 1845348 reaction equation
CC([N:5]([C@@H:9]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:10][N:11]1[C:19](=[O:20])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]1=[O:21])C(=O)[O-])(C)C.Cl>CO.O1CCOCC1>[NH2:5][C@@H:9]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:10][N:11]1[C:19](=[O:20])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]1=[O:21]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86633538HCID 86633538, compound

Product 1

HCID 57826527HCID 57826527, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 1,1-dimethylethyl[(1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-(phenylmethyl)ethyl]carbamate (4.3 g, 11.3 mmole) in MeOH (100 mL) at RT was added 4M HCl in dioxane (50 mL). After stirring for 3 h at RT, the reaction solution was concentrated to a white solid (quant.): LCMS (ES) m/z 281 (M+H)+.

Workup

  1. concentrationthe reaction solution was concentrated to a white solid (quant.)

Sources & evidence

ORD record
ord-c8eb5f39d7214038837c60e5e4a2e423
Source dataset
uspto-grants-2015_02
Patent number
US08946278B2

Reaction notes

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