Citric Acid → 2-[1-(2-chloro-6-cyanophenyl)pyrazolo[5,4-d]pyrimidin-4-yl]oxy-N-(5-methylpyrazin-2-yl)-3-[1-tri(propan-2-yl)silyloxypropan-2-yloxy]propanamide
Reaction equation
[CH2:63]1[O:64][CH2:65][CH2:66][CH2:67]1.[Cl:31][c:32]1[c:33](-[n:40]2[n:41][cH:42][c:43]3[c:44]2[n:45][cH:46][n:47][c:48]3[Cl:49])[c:34]([C:35]#[N:36])[cH:37][cH:38][cH:39]1.[H-:1].[Na+:2].[OH:3][CH:4]([C:5](=[O:6])[NH:7][c:8]1[n:9][cH:10][c:11]([CH3:14])[n:12][cH:13]1)[CH2:15][O:16][CH:17]([CH2:18][O:19][Si:20]([CH:21]([CH3:22])[CH3:23])([CH:24]([CH3:25])[CH3:26])[CH:27]([CH3:28])[CH3:29])[CH3:30].[OH:50][C:51]([CH2:52][C:53]([C:54](=[O:55])[OH:56])([CH2:57][C:58](=[O:59])[OH:60])[OH:61])=[O:62]>>[O:3]([CH:4]([C:5](=[O:6])[NH:7][c:8]1[n:9][cH:10][c:11]([CH3:14])[n:12][cH:13]1)[CH2:15][O:16][CH:17]([CH2:18][O:19][Si:20]([CH:21]([CH3:22])[CH3:23])([CH:24]([CH3:25])[CH3:26])[CH:27]([CH3:28])[CH3:29])[CH3:30])[c:48]1[c:43]2[cH:42][n:41][n:40](-[c:33]3[c:32]([Cl:31])[cH:39][cH:38][cH:37][c:34]3[C:35]#[N:36])[c:44]2[n:45][cH:46][n:47]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-89a192bdd9b04b4ab92f76ea7d108f17
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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