Hydroxyamine hydrochloride → HCID 136412248, compound

HRID 18455Notes

Reaction equation

HRID 18455 reaction equation
[OH:1][C:2]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH:7]=[CH:6][C:3]=1[CH:4]=O.Cl.[NH2:20][OH:21]>CCO>[OH:1][C:2]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH:7]=[CH:6][C:3]=1[CH:4]=[N:20][OH:21]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 10060673Benzaldehyde, 2-hydroxy-4-(octyloxy)-

Product 1

HCID 136412248HCID 136412248, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-hydroxy-4-octyloxy-benzaldehyde (3.64 g; 14.5 mmol) in abs. EtOH (30 mL) was added hydroxylamine hydrochloride [50% H2O (w/w)] and the slurry was stirred for 2 hours. The reaction mixture was evaporated to dryness and the resulting solid triturated in H2O (20 mL) and EtOAc/diethylether (20 mL+10 mL) to give 1.8 g (47%) as a white solid. MS (direct; EI): 265 (M).

Workup

  1. customThe reaction mixture was evaporated to dryness
  2. customthe resulting solid triturated in H2O (20 mL)
  3. customEtOAc/diethylether (20 mL+10 mL) to give 1.8 g (47%) as a white solid

Sources & evidence

ORD record
ord-f962c26bb26c4a7c91021c4dea22b8c4
Source dataset
uspto-grants-2010_06
Patent number
US07741352B2

Reaction notes

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