Silver Nitrate → Silver Nitrate

HRID 1845712Notes

Reaction equation

HRID 1845712 reaction equation
[CH:1]1[C:6]([NH:7][C:8]([NH:10][C:11]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]([NH:23][C:24]([NH:26][C:27]2[CH:28]=[CH:29][C:30]([Cl:33])=[CH:31][CH:32]=2)=[NH:25])=[NH:22])=[NH:12])=[NH:9])=[CH:5][CH:4]=[C:3]([Cl:34])[CH:2]=1.[N+:35]([O-:38])([O-:37])=[O:36].[Ag+:39].[Al]>C(OC)(=O)C.CC(C)=O>[CH:28]1[C:27]([NH:26][C:24]([NH:23][C:21]([NH:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][NH:13][C:11]([NH:10][C:8]([NH:7][C:6]2[CH:1]=[CH:2][C:3]([Cl:34])=[CH:4][CH:5]=2)=[NH:9])=[NH:12])=[NH:22])=[NH:25])=[CH:32][CH:31]=[C:30]([Cl:33])[CH:29]=1.[N+:35]([O-:38])([O-:37])=[O:36].[Ag+:39].[N+:35]([O-:38])([O-:37])=[O:36].[Ag+:39]

Participants

6

Reactant 3

HCID 24470Silver Nitrate3×HCID 5359268AluminumHCID 178512157Chlorohexidine2×

Product 2

HCID 24470Silver NitrateHCID 178512163HCID 178512163, compound

Reagents, catalysts & solvents 1

HCID 19782830Methyl acetate acetoneSolvent

Procedure

The chlorhexidine/silver nitrate formulation was prepared by dissolving 22.5 mg of chlorhexidine (3% w/w based on the dried film weight) in 10 ml of a methyl acetate/acetone solvent mixture (70/30, vol/vol) at room temperature with gentle swirling. The chlorhexidine dissolved quickly to yield a clear solution. Next, 750 mg of the polymer of Example 1 (7.5% weight/volume) was added to the solution. The solution was agitated and shaken gently to facilitate dissolution of the polymer. Upon complete dissolution of the polymer after approximately 6 hours, 150 mg of silver nitrate crystals (excess) was added to the solution in a roller bottle. The roller bottle was wrapped with aluminum foil and placed on a rolling apparatus for sufficient time to permit dissolved silver nitrate to come to equilibrium with the remaining solid silver nitrate to produce a saturated silver nitrate solution. After approximately 16 hours, the solution was filtered through 0.45 μm Acrodisc filters to remove the undissolved silver nitrate and collected in a clean vial for future use. The vial containing the filtered solution was wrapped with aluminum foil to avoid contact with light and stored at 4° C.

Workup

  1. customat room temperature
  2. customto yield a clear solution
  3. stirringshaken gently
  4. dissolutiondissolution of the polymer
  5. dissolutionUpon complete dissolution of the polymer after approximately 6 hours

Sources & evidence

ORD record
ord-7822318f0a22420bad560502cc7f7628
Source dataset
uspto-grants-2015_02
Patent number
US08951552B2

Reaction notes

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